Humberto Loayza competed as a welterweight at the 1948 Olympics, losing before the quarter-finals. He turned professional after the Olympics and fought from 1949-64 in the pro ranks, exclusively in South America. His career record was 39 wins (24 by KO), 22 losses, and 6 draws. In September 1953 he won the Chilean middleweight title, losing it in his next bout, but he regained the title in July 1955 with a 9th-round knockout of Pacifico Campos. One month later, Loayza added the Chilean light-heavyweight title, but he lost both crowns in mid-1956. He again won the Chilean middleweight belt in January 1958 and November 1959, holding them each time for less than a year. Finally, Loayza again won the Chilean middleweight championship in January 1964 by defeating David Ossandon on points, after which Loayza retired, relinquishing the title. He fought for the South American middleweight crown in June 1956 and March 1958, and for the South American light-heavyweight crown in January 1961, but he lost all three bouts.