Zaki Osman, as well as his brother Gamil, were members of a prominent Egyptian political family, but both were also pioneers in the country’s football scene. Both took part in the tournament at the 1920 Antwerp Olympics, where Egypt was eliminated by Italy in round one. Domestically, Zaki was a star for Al-Ahly and won the Sultan Hussein Cup four times (1923 and 1925-1927), the Egypt Cup four times (1924-1925, 1927-1928), and the Cairo League three times (1925, 1927-1928).
Following his retirement from active competition, Osman went on to have an extensive career as a football administrator and international referee. Most notably in the latter case, he was a linesman in the Turkey — Curaçao match at the 1952 Helsinki Olympic football tournament. At the time of his death, he was the last surviving member of the Egyptian squad at the 1920 Games. By career, he was an engineer and served in political administrative capacities in Cairo.