Lotte Mühe won a bronze medal at the 1928 Amsterdam Olympics in the 200 metre breaststroke, also placing second at the 1927 European Championships. In 1928 and 1929 she won German Championships, adding another in 1928 with the 3x100 breaststroke relay, after finishing second in that event in 1927. In 1927, she set two world records in the 100 (1:12.2) and the 200 (3:16.6) breaststroke, and in 1928 she swam on breaststroke relays that set another two world marks. Mühe also set three European and two German records.