Sharon Cain played college basketball at Odesa Junior College where she led her conference in assists and steals. After college she joined the US National handball team in 1989 and played with them through 1999. Cain, a center back, won a gold medal at the 1995 Pan American Games and played at the 1999 Pan Ams, where the team finished fourth. She also competed at the 1993 and 1995 World Championships. She was the 1994 US Handball Federation Female Player of the Year. Cain was known for her devotion to physical fitness, always training, lifting weights, and carefully watching her diet and nutrition.