Edwin Knox made the 1936 Olympic water polo team but an injury prevented him from traveling to Berlin. He played for the Los Angeles Athletic Club (LAAC) and also played at Long Beach City College and UCLA, graduating from there in 1936. He helped the LAAC win AAU titles in 1941 and 1947-48. Knox led UCLA to Pacific Coast Conference (PCC) titles in 1934-36. He captained Long Beach in 1932 and UCLA in 1935-36 and was named to the PCC all-conference team in 1935-36. Knox also captained the LAAC team in 1947-48. He was inducted into the US Water Polo Hall of Fame in 1983.