Amédée Thubé was one of the sons of the Nantes shipowner Gaston Thubé, Sr., who introduced his sons to sailing in Brittany. He was married to Marguerite Marie Nazli Denaut, daughter of a diplomat. Their son Marc Thubé (1919-1997) served in the Commandos Kieffer during the allied landing in Normandy. Together with his older brothers Gaston and Jacques he won the first sailing gold for France at the 1912 Olympic Games in the 6 metres class. In the duel of the Danish Nurdug II and the French Mac Miche with Gaston Thubé at the helm, the two yachts tied after two races. In the match-race for gold, Mac Miche won convincingly by almost three minutes to claim gold. Amédée also owned a race horse.
During the World War I, Thubé served as a warrant officer in the French maritime aviation and was awarded the Croix de Guerre and the Military Medal. Later, he became director of the family-owned Calvé-Delft oil mill. Around 1930, he settled in Paris and got involved in commercial affairs in French West Africa and later French Equatorial Africa, for instance as president of the French Company of the Ivory Coast, the French Niger Company, and director of the Colonial Fruits Commercial Company.